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Kun-Soo Kim, Ph.D.  : Molecular Interactions between Bacteria and Eukaryotes
 
Office: R217   /   Phone: +82-2-705-8460   /   E-Mail : kskim@sogang.ac.kr
Research Interests
Molecular interactions between pathogenic bacteria and higher organisms medicated by diffusible signal molecules.
Two model systems are currently employed; (1) Interactions between V. vulnificus and human. (2) Interactions between A. tumefaciens and plant.
Selected Publications
Lee BC, Lee JH, Kim MW, Kim BS, Oh MH, Kim KS, Kim TS, Choi SH.
Vibrio vulnificus rtxE is important for virulence, and its expression is induced by exposure to host cells. Infect Immun (2008) 76:1509-1517

Goo SY, Lee HJ, Kim WH, Han KL, Park DK, Lee HJ, Kim SM, Kim KS, Lee KH, Park SJ. Identification of OmpU of Vibrio vulnificus as a fibronectin-binding protein and its role in bacterial pathogenesis. Infect Immun (2006) 74: 5586-5594

Park DK, Lee KE, Baek CH, Kim IH, Kwon JH, Lee WK, Lee KH, Kim BS, Choi SH, Kim KS. Cyclo(Phe-Pro) modulates the expression of ompU in Vibrio spp. J Bacteriol (2006) 188:2214-2221

Seong-Ryong  Kim, Ph.D.  : Plant Molecular Biology Laboratory
 
Office: R1105   /   Phone: +82-2-705-8456   /   E-Mail: sungkim@sogang.ac.kr
Research Interests
Physiology, biochemistry, and genetics of the stress responsive genes in both plant vegetative and reproductive organs
Selected Publications
Koh S, Lee SC, Kim MK, Koh JH, Lee S, An G, Choe S, Kim SR. T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of Arabidopsis BIN2, with enhanced tolerance to various abiotic stresses. Plant Mol. Biol. (2007) 65:453-466

Kim SH, Kim JY, Kim SJ, An KS, An G, Kim SR. Isolation of cold stress-responsive genes in the reproductive organs, and characterization of the OsLti6b gene from rice (Oryza sativa L.) Plant Cell Rep. (2007) 26:1097-1110

Jeong DH, An S, Park S, Kang HG, Park GG, Kim SR, Sim J, Kim YO, Kim MK, Kim SR, Kim J, Shin M, Jung M, An G. Generation of flanking sequence tag database for activation tagging lines in japonica rice. Plant J. (2006) 45:123-132

Won-Sun Kim, Ph.D.  : Developmental Biology Research Laboratory
 
Office: R1121   /   Phone: +82-2-705-8453   /   E-Mail: wskim@sogang.ac.kr
Research Interests
Xenopus Development
Amphibian Limb Development & Regeneration
Selected Publications
Seo YW, Sanyal S, Kim HJ, Won DH, An JY, Amano T, Zavacki AM, Kwon HB, Shi YB, Kim WS, Kang H, Moore DD, Choi HS. FOR, a novel orphan nuclear receptor related to farnesoid X receptor. J Biol Chem. (2002) 277:17836-17844

Lee SY, Kim WS, Yang JM. Expression patterns of Fgf-8 during development and limb regeneration of the axolotl. Dev Dyn. (2001) 220:40-48

Han MJ, An JY, Kim WS. Expression and characterization of fibroblast growth factor 8 from Mexican axolotl, Ambystoma mexicanum. Mol Cells (2000)10:684-691

Jungho Kim, Ph.D.  : Laboratory for Molecular and Cellular Biology
 
Office: R1201   /   Phone: +82-2-705-8461   /   E-Mail: jkim@sogang.ac.kr
Research Interests
Cancer Research
Stem Cell Research
Cancer Stem Cell Research
Selected Publications
Kim S, Lee HJ, Jun HJ, Kim J. The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator. Int. J. Cancer (2008) 122: 2446-2453

Lee J, Kim JY, Kang IY, Kim HK, Han YM, Kim J. The EWS-Oct-4 fusion gene encodes a transforming gene. Biochem. J. (2007) 406: 519-526

Lee J, Kim HK, Rho JY, Han YM, Kim J. The human OCT-4 isoforms differ in their ability to confer self-renewal. J. Biol. Chem. (2006) 281: 33554-33565

Young Woo Nam, Ph.D  : Plant Developmental Physiology Laboratory
 
Office: R1107   /   Phone: +82-2-705-8792   /   E-Mail: ywnam@sogang.ac.kr
Research Interests
Molecular genetic analysis of nodulation-associated genes in legumes
Comparative genome analysis using large-insert libraries
Selected Publications
Song KH, Song DH, Lee JR, Kim GB, Choi HK, Penmetsa RV, Nam YW.
Cloning and characterization of Δ1-pyrroline-5-carboxylate synthetase genes and identification of point mutants in Medicago truncatula. Korean Journal of Crop Science (2007) 52: 458-468

Park SY, Nam YW. Construction of bacterial artificial chromosome library containing large BamHI genomic fragments from Medicago truncatula and identification of clones linked to hyper-nodulating genes. J. Microbiol. Biotechnol. (2006) 16: 256-263

Song KH, Nam YW. Genomic organization and differential expression of two polygalacturonase-inhibiting protein genes from Medicago truncatula. Journal of Plant Biology (2005) 48, 467-478.

Hyung-Doo Shin, Ph.D.  : Laboratory for Genomic Diversity
 
Office: K527   /   Phone: +82-2-705-8615   /   E-Mail: hdshin@sogang.ac.kr
Research Interests
Human genetic variation (SNP,CNV) research for personalized medicine
Development of epigenetic biomarkers for human disease
Selected Publications
Yasuda K et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature Genetics (2008) 40:1092-1097

Kim DJ, Choi IG, Park BL, Lee BC, Ham BJ, Yoon S, Bae JS, Cheong HS, Shin HD. Major genetic components underlying alcoholism in Korean population. Human Molecular Genetics (2008) 17: 854-858

Lee JH, Moore JH, Park SW, Jang AS, Uh ST, Kim YH, Park CS, Park BL, Shin HD. Genetic interactions model among Eotaxin gene polymorphisms in asthma. J Hum Genet. (2008) 53:867-875

Gap Ryol Lee, Ph.D.  : Molecular Immunology Laboratory
 
Office: R1123   /   Phone: +82-2-705-8458   /   E-Mail: grlee@sogang.ac.kr
Research Interests
Signal transduction and gene regulation in T helper cells
Development of therapeutic strategies to treat allergy and asthma
Selected Publications
Lee GR, Kim ST, Spilianakis CG, Fields PE, Flavell RA. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity (2006) 24: 369-379

Lee GR, Spilianakis CG, Flavell RA. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol. (2005) 6:42-48

Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature (2005) 435: 637-645

 

Kyu-Ho Lee, Ph.D. : Molecular Microbiology and Biofilm Laboratory
Office: K232 / Phone: +82-2-705-7963 / E-Mail: kyuholee@sogang.ac.kr
Research Interests
Biofilm formation by a pathogenic bacterium, Vibrio vulnificus
Quorum-sensing regulatory mechanisms in Vibrio vulnificus
Host-interacting components of Vibrio vulnificus: Adhesin
Transcriptional regulatory networks for pathogenicity of Vibrio vulnificus
Selected Publications

Lee, K.-J., C.-S. Jeong, Y. J. An, H.-J. Lee, S.-J. Park, Y.-J. Seok, P. Kim, J.-H. Lee, K.-H. Lee*, and S.-S. Cha*. 2011. FrsA functions as a cofactor-independent decarboxylase to control metabolic flux. Nature Chemical Biology. 7:434-436.

Kim, H.-S., S.-J. Park, and K.-H. Lee. 2009. Role of NtrC-regulated exopolysaccharides in the biofilm formation and pathogenic interaction of Vibrio vulnificus. Molecular Microbiology. 74(2):436-453.


Lee, H.-J., S.-J. Park, S. H. Choi, and K.-H. Lee. 2008. Vibrio vulnificus rpoS expression is repressed by direct binding of cAMP-CRP complex to its two promoter regions. Journal of Biological Chemistry. 283(45):30438–30450.

Byung Ha Lee, Ph.D.  : Plant Developmental Physiology Laboratory
 
Office: RA201-1   /   Phone: +82-2-705-8794   /   E-Mail: byeongha@sogang.ac.kr
Research Interests
Stress Signal transduction in Arabidopsis
Stress-Regulated Gene Expression in Arabidopsis
Plant Developmental Program Regulation
Selected Publications
Lee BH, Kapoor A, Zhu J, Zhu JK. STABILIZED1, a Stress-Upregulated Nuclear Protein, Is Required for Pre-mRNA Splicing, mRNA Turnover, and Stress Tolerance in Arabidopsis. Plant Cell (2006) 18, 1736-1749.

Dong CH, Hu X, Tang W, Zheng X, Kim YS, Lee BH, Zhu JK. A putative Arabidopsis nucleoporin AtNUP160 is critical for RNA export and required for plant tolerance to cold stress. MCB (2006) 26, 9533-9543.

Lee BH, Henderson DA, Zhu JK. The Arabidopsis cold-responsive transcriptome and its regulation by ICE1. Plant Cell (2005) 17, 3155-3175.

Jeong kug Lee, Ph.D.  : Microbial Biomolecule Research Laboratory
 
Office: R207   /   Phone: +82-2-705-8459   /   E-Mail: jgklee@sogang.ac.kr
Research Interests
Bioenergy production by microorganisms
Oxidative stress defense in microorganisms
Structural and functional characterization of proteins with novel functions
Selected Publications
Kim JS, Choi SH, Lee JK. Lysine decarboxylase expression of Vibrio vulnificus is induced by SoxR in response to superoxide stress. J Bacteriol. (2006)188: 8586-8592.

Rhee HJ, Kim EJ, Lee JK. Physiological polyamines: simple primordial stress molecules. J. Cell. Mol. Med. (2007)11: 685-703.

Kim EJ, Kim JS, Lee IH, Rhee HJ, Lee JK. Superoxide generation by chlorophyllide a reductase of Rhodobacter sphaeroides.
J. Biol. Chem. (2008) 283: 3718-3730.

Jung-Ha Lee, Ph.D  : Animal Physiology Laboratory
 
Office: R1119   /   Phone: +82-2-705-8791   /   E-Mail: jhleem@sogang.ac.kr
Research Interests
Neurophysiolgy
Electrophysiology
Ion channels
Neural excitability
Selected Publications
Kang HW, Park JY, Lee JH. Distinct contributions of different structural regions to the current kinetics of the Ca(v)3.3 T type Ca(2+) channel. Biochim. Biophys. Acta. (2008). In press

Kang HW, Moon HJ, Joo SH, Lee JH. Histidine residues in the IS3-IS4 loop are critical for nickel inhibition of the Cav2.3 channel. FEBS Letters (2007) 581:5774-5780

Nelson MT, Joksovic PM, Su P, Kang HW, Van Deusen A, Baumgart JP, David LS, Snutch TP, Barrett PQ, Lee JH, Zorumski CF, Perez-Reyes E, Todorovic SM. Molecular mechanisms of subtype-specific inhibition of T-type channels by ascorbate. The Journal of Neuroscience (2007) 27:12577-12583

Jai Myung Yang, Ph.D.  : Virology Laboratory
 
Office: R203   /   Phone: +82-2-705-8457   /   E-Mail: jaimyang@sogang.ac.kr
Research Interests
1. Biochemical properties and RNA replication mechanisms of norovirus RdRp.
2. Molecular mechanism of arginine peptide-mediated gene delivery system.
3. Development of anthrax DNA vaccine.
4. Development of an efficient gene delivery system into mesenchymal stem cells.
Selected Publications
Kim NY, Kim HG, Kim YH, Chung IS, Yang JM. Expression and characterization of human N-acetylglucosaminyltransferases and α2,3-sialyltransferase in insect cells for in vitro glycosylation of recombinant erythropoietin. J. Microbiol. Biotechnol. (2008) 18 : 383-391

Chang KH, Lee JM, Hwang-Bo J, Yoo KH, Sohn BH, Yang JM, Chung IS.
Expression of recombinant cyclooxygenase 1 in Drospophila melanogaster S2 cells transformed with human β1,4-galactosyltransferase and Galβ1,4-GlcNAc α2,6-sialyltransferase. Biotechnology Letters (2007) 29: 1803-1809

Kim HH, Choi HS, Yang JM, Shin S .Characterization of gene delivery in vitro and in vivo by the arginine peptide system. Int J Pharm. (2007) 335: 70-78

Kwang-Hwan Jung, PhD  : Protein Biochemistry Laboratory
 
Office: R1203   /   Phone: +82-2-705-8795   /   E-Mail: kjung@sogang.ac.kr
Research Interests
Photosensory Receptor & Signal Transduction
Photo-Energy Conversion & Optical Switch
Selected Publications
Kim SY, Waschuk SA, Brown LS, Jung KH. Screening and Characterization of Proteorhodopsin Color-Tuning Mutations in Escherichia coli with Endogenous Retinal Synthesis. BBA-Bioenergetics (2008)1777:504-513.

Jung JY, Choi AR, Lee YK, Lee HK, Jung KH. Spectroscopic and photochemical analysis of proteorhodopsin variants from the surface of the Arctic Ocean. FEBS Letters-Biophysics (2008) 582:1679-1684.

Jung KH. The distinct signaling mechanisms of microbial sensory rhodopsins in Archaea, Eubacteria, and Eukarya. Photochem. Photobiol. (2008) 83:63-69.

Bong-Gun Ju, Ph.D.  : Cell Differentiation Laboratory
 
Office: R213   /   Phone: +82-2-705-8455   /   E-Mail: bgju@sogang.ac.kr
Research Interests
Stem Cell Differentiation
DNA damage Response
Cancer Biology
Selected Publications
Lunyak VV, Prefontaine GG, Núñez E, Cramer T, Ju BG, Ohgi KA, Hutt K, Roy R, García-Díaz A, Zhu X, Yung Y, Montoliu L, Glass CK, Rosenfeld MG. Developmentally regulated activation of a SINE B2 repeat as a domain boundary in organogenesis. Science (2007) 317: 248-251

Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG. A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 312:1798-1802

Hyun Jin Cha, Ph.D.  : Cellular Signaling Laboratory 
 
Office: K523   /   Phone: +82-2-705-4761  /   E-Mail: hjcha@sogang.ac.kr
Research Interests
- Molecular mechanism of aging in Stem cells
- Molecular mechanism of generation of cancerous stem cells.
- Cell cycle regulation of Stem cells
- Ionizing radiation(IR) response in Stem Cells
Selected Publications

Cha Y, Moon BH, Lee MO, Ahn HJ, , Lee HJ Lee KA, Fornace AJ, , Cha HJ*, Park KS*, “ZAP-70 expression in mouse embryonic stem cells and functional role in stemness control” Stem Cells 2010, Jul 16 (IF:7.741)  (* Co-PI)

Lee JS, Moon BH, Lee MO, Shim SH, Fornace AJ, Cha HJ*. Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways. Stem Cells, 2009.Aug;27(8):1963-1975 (IF : 7.741)


Ching Tack Han, Ph.D.  : Cellular Biochemistry Research Laboratory
 
Office: R1211   /   Phone: +82-2-705-8458   /   E-Mail: cthan@sogang.ac.kr
Research Interests
Heat shock response in C. elegance
Selected Publications
Kim SJ, Yune TY, Han CT, Kim YC, Oh YJ, Markelonis GJ, Oh TH. Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH-SY5Y cells against oxidative stress. J. Neurosci Res. (2007) 85:139-152

Son WY, Han CT, Lee JH, Jung KY, Lee HM, Choo YK. Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice. Dev Growth Differ. (2002) 44:181-90.
 
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