Bio Robot


Bioelectronics is a coined term for a field of research that works to establish a synergy between electronics and biology. The emerging field of Bioelectronics seeks to exploit biology in conjunction with electronics in a wider context encompassing, for example, biological fuel cells, bionics and biomaterials for information processing, information storage, electronic components and actuators. A key aspect is the interface between biological materials and micro- and nano-electronics.


Protein-based Electronic Devices

Our team developed many kinds of protein-based electronic devices including biomemory, biotransistor, bioprocessor. To realize those bioelectronics devices, we introduced metalloprotein for core functional material with its redox property. Furthermore, we also produced biomaterial complex by combine metalloprotein with other protein or organic/inorganic materials to give specific functions like electrochemical signal enhancement and regulation.



Toward Bio Robot

Our current research goal is to develop biocomputing system and bioelectronic medicine by using biomolecuels with other functional materials. To achieve this goal, we will develop the Biomoletron, which is biological hybrid material with computational functions for biocomputer and with metabolism controllable materials for bioelectronic medicine application.



Holding Techniques

We have technique of recombinant protein modification for attachment of thiol group on metalloprotein to immobilize on the Au substrate directly. Also, we can fabricate various biological complex such as DNA/protein complex and protein-protein complex for bioelectronic application. Using self-assembly technique, we can immobilize biomolecular mono-layer on the chip substrate to fabricate bioelectronic devices. We are using various metalloproteins such as cytochrome c, azurin, ferritin, myoglobin and so on. To observe the self-assembled layer formation, we use surface plasmon resonance (SPR). Also, the surface morphology of self-assembled layer was observed by scanning probe microscopy (SPM) observation. Electrochemical properties of metalloproteins were investigated by cyclic voltammetry (CV) or differential pulse voltammetry (DPV) technique. Using chronoamperometry (CA) and open circuit potential amperometry (OCPA), memory function of metalloproteins was verified. We also have techniques like scanning tunneling microscopy (STM) and electrochemical scanning tunneling microscopy (EC-STM) for electrochemical investigation.



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